Pentapeptide-18, commercially known as Leuphasyl, is a biomimetic peptide designed to reduce expression wrinkles by targeting the skin’s neuromuscular activity.
At West Lab Chemicals, we supply Leuphasyl 200mg (Topical Grade) with ≥99% HPLC-tested purity, formulated specifically for cosmetic research and peptide-based skincare development.
Leuphasyl acts as a neuropeptide modulator, helping to relax facial muscle contractions and minimize dynamic wrinkles, making it a popular ingredient in anti-aging and firming formulations.
What is Pentapeptide-18 (Leuphasyl)?
Pentapeptide-18 is a synthetic peptide with the amino acid sequence Tyr-D-Ala-Gly-Phe-Leu, derived from enkephalin, a natural neurotransmitter.
It works by interfering with acetylcholine release at the neuromuscular junction, similar in concept to botulinum toxin (Botox®) but in a non-invasive, topical form.
This action helps reduce the depth of expression lines, especially around the forehead, eyes, and mouth, offering a relaxing, wrinkle-smoothing effect over time.
Key Features
✅ ≥99% purity (HPLC verified)
✅ Reduces facial muscle contractions
✅ Softens expression lines and dynamic wrinkles
✅ Improves smoothness and firmness of the skin
✅ Non-invasive, needle-free wrinkle solution
✅ Compatible with Argireline (Acetyl Hexapeptide-8) for enhanced results
✅ Ideal for cosmetic and dermatological research
Benefits
✨ Wrinkle Reduction: Minimizes expression lines by targeting neurotransmitter activity.
✨ Botox-Like Mechanism: Topical relaxation of facial muscles for a smoother appearance.
✨ Non-Invasive: Safe, needle-free alternative to injectables.
✨ Anti-Aging Synergy: Works well with Argireline and Matrixyl for comprehensive anti-wrinkle formulations.
✨ Visible Results: Continuous use enhances firmness and elasticity within 4–8 weeks.
Applications / Uses
🔹 Anti-aging serums and creams
🔹 Expression-line and wrinkle treatment products
🔹 Eye contour and forehead wrinkle formulas
🔹 Daily peptide-based skincare
🔹 Cosmetic neuropeptide research
Composition & Technical Data
| Property | Specification |
|---|---|
| Chemical Name | Pentapeptide-18 |
| Commercial Name | Leuphasyl |
| Sequence | Tyr-D-Ala-Gly-Phe-Leu |
| CAS Number | 64963-01-5 |
| Molecular Formula | C₃₀H₄₈N₆O₇ |
| Molecular Weight | 604.75 g/mol |
| Appearance | White to off-white lyophilized powder |
| Purity | ≥99 % (HPLC verified) |
| Solubility | Soluble in water |
| Form | Lyophilized powder (Topical research grade) |
| Storage Conditions | 2 – 8 °C, dry and dark |
| Pack Size | 200 mg vial |
Dosage & Usage
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Recommended concentration: 0.5% – 5% in topical formulations
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Solvent: Dissolve in sterile distilled water prior to formulation blending
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Application: Apply to expression-prone areas (forehead, eyes, mouth) once or twice daily
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Visible Results: 4–8 weeks of consistent use
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Compatibility: Synergistic with Argireline (Acetyl Hexapeptide-8) and Matrixyl (Palmitoyl Pentapeptide-4)
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Note: For research and topical formulation use only; not for injection or ingestion
Storage & Stability
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Store sealed vial at 2–8 °C in a cool, dry, dark environment.
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After reconstitution, aliquot and freeze at –20 °C.
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Avoid multiple freeze-thaw cycles.
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Protect from light and moisture.
Safety & Handling
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For cosmetic formulation and research use only.
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Not intended for human or veterinary use.
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Avoid direct eye and mucous membrane contact.
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Use gloves and laboratory safety gear when handling.
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Dispose of residual materials according to local regulations.
Why Buy from West Lab Chemicals?
🌐 High Purity: ≥99% verified by HPLC & Mass Spectrometry
🧪 COA Supplied: Every batch includes a Certificate of Analysis
🏭 GMP-Compliant Production: Manufactured under controlled laboratory conditions
🚚 Fast Global Shipping: Secure, temperature-controlled packaging
💬 Expert Support: Technical guidance for solubility and peptide formulation
💧 Trusted Worldwide: Preferred by cosmetic labs and R&D formulators
Purity Guarantee
Each batch of Leuphasyl (Pentapeptide-18) from West Lab Chemicals undergoes:
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HPLC and MS purity verification
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Endotoxin and microbial safety testing
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COA batch traceability
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Cosmetic-grade certification (≥99% purity)

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